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2021-03-30
Cellular glutathione is a key to the oxygen effect in radiation damage; PY1978;
USA (美國);_WJD_2021-0330_V001R01_IR94_RvD20210330_
Source (資訊來源):
https://www.nature.com/articles/271660a0
Info cited on 2021-03-30-WD2 (資訊引用於 中華民國110年西元2021年3月30日) by 湯偉晉 (WeiJin Tang)
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Published: 16 February 1978
Cellular glutathione is a
key to the oxygen effect in radiation damage
M. L. MORSE & ROLF H. DAHL
Nature volume 271, pages660–662(1978)Cite this article
Abstract
OXYGEN is known to enhance
biological changes induced by ionizing radiation (游離輻射). The changes include chromosome breaks in
Tradescantia, mutation production in Drosophila, maize and bacteria, and rate
of mitosis in grasshopper neuroblasts7. The biological and physical bases for the various
enhancements remain obscure, and it has not yet been established that they are the result of a common mechanism. The quantitative
aspects of the relationship between oxygen concentration and radiation response
have been measured: for example, killing of Escherichia coli by X-ray radiation
at a constant radiation dose and various interpretations of the quantitative
aspects of the response base have been made. Ionizing radiation (游離輻射) has been proposed
to interact with water to produce several products and these products interact
with cellular material to produce the biological effects observed. In the reactions
proposed, cellular
sulphydryl groups are supposed to be a primary cellular constituent which is
reactive with the radiation products from water. We report here that one major cellular sulphydryl
constituent, glutathione
(GSH), is apparently
the major component in the interaction between radiation products and the cell,
for cells unable to synthesize glutathione cannot be protected against killing by ionizing
radiation (游離輻射) by reduction of the
external oxygen concentration.
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