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2020-06-01
Important Components of the UW Solution; PY1990; University of Wisconsin;_WJD_2020-0601_V001R01_IR94_RvD20200601_
Source (資訊來源):
https://pubmed.ncbi.nlm.nih.gov/1689516/
Info cited on 2020-06-01-WD1 (資訊引用於 中華民國109年6月1日) by 湯偉晉 (WeiJin Tang)
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UW Solution
University of Wisconsin solution (威斯康辛大學溶液)
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Transplantation
1990 Feb;49(2):251-7. doi: 10.1097/00007890-199002000-00004.
Important Components
of the UW Solution
J H Southard 1, T M van Gulik, M S Ametani, P K Vreugdenhil, S L Lindell, B L
Pienaar, F O Belzer
Affiliation
1Department of Surgery, University
of Wisconsin, Madison 53792.
PMID: 1689516 DOI: 10.1097/00007890-199002000-00004
Abstract
The UW solution for preservation of the liver, kidney, and pancreas contains a
number of components, and the importance of each of these has not been fully
resolved. In the studies reported here the importance of glutathione and adenosine is
demonstrated in isolated cell models (rabbit renal tubules and rat liver
hepatocytes) of hypothermic preservation and reperfusion and in dog renal
transplantation. Glutathione
in the UW solution is necessary for the preservation of the capability of the
cell to regenerate ATP and maintain membrane integrity. Adenosine in the UW solution
provides the preserved cell with substrates for the regeneration of ATP during
the reperfusion period following cold storage. The omission of GHS from
the UW solution results in poorer renal function in the 48 hr dog kidney
preservation-transplant model. The role of other components of the UW solution
is discussed including lactobionic acid; other impermeants; and the colloid,
hydroxyethyl starch. It is concluded that the development of improved
preservation solutions will require a more detailed understanding of the
mechanism of injury due to cold storage and, once obtained, solutions more
complex than the UW solution may be required for improved long-term storage of
organs.
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