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2020-08-04
Inhibitory effects of glutathione on dengue virus production;
PY2010; PR China (中華人民共和國);_WJD_2020-0804_V001R01_IR94_RvD20200804_
Source (資訊來源):
https://www.sciencedirect.com/science/article/abs/pii/S0006291X10010235
Info cited on 2020-08-04-WD2 (資訊引用於 中華民國109年8月4日) by 湯偉晉 (WeiJin Tang)
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Biochemical and Biophysical Research Communications
Volume 397, Issue 3, 2 July 2010, Pages 420-424
Inhibitory effects of
glutathione on dengue virus
production
Abstract
Reduced glutathione (GSH) is the most powerful
intracellular antioxidant and also involved in viral infections. The
pathogenesis of dengue virus (DV) infection has not been completely clarified.
This study investigated the relationship between DV serotype 2 (DV2) infections
and host intracellular GSH
content. Results showed infection with DV2 resulted in a decrease in
intracellular GSH,
which caused NF-κB activation and increased DV2 production. Supplemental GSH significantly inhibited
activation of NF-κB, resulting in a decreased production of DV2 in HepG2 cells.
Furthermore, high activity of NF-κB and increased production of DV2 was
observed in HepG2 cells treated with buthionine sulfoximine (BSO), an inhibitor
of GSH synthesis. In
conclusion, DV2 infection could reduce host intracellular GSH concentration and
benefited from this process. Supplemental GSH could inhibit viral production, indicating GSH might be valuable in the
prevention and treatment of DV2 infection.
Keywords
Dengue virus, Redox stage, GSH,
NF-κB
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