2020年8月4日 星期二

Inhibitory effects of glutathione on dengue virus production; PY2010; PR China (中華人民共和國);_WJD_2020-0804_IR94_

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2020-08-04
Inhibitory effects of glutathione on dengue virus production; PY2010; PR China (
中華人民共和國);_WJD_2020-0804_V001R01_IR94_RvD20200804_

Source (
資訊來源):
https://www.sciencedirect.com/science/article/abs/pii/S0006291X10010235
Info cited on 2020-08-04-WD2 (
資訊引用於 中華民國10984) by 湯偉晉 (WeiJin Tang)
#

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Biochemical and Biophysical Research Communications
Volume 397, Issue 3, 2 July 2010, Pages 420-424

Inhibitory effects of glutathione on dengue virus production

Abstract
Reduced glutathione (GSH) is the most powerful intracellular antioxidant and also involved in viral infections. The pathogenesis of dengue virus (DV) infection has not been completely clarified. This study investigated the relationship between DV serotype 2 (DV2) infections and host intracellular GSH content. Results showed infection with DV2 resulted in a decrease in intracellular GSH, which caused NF-κB activation and increased DV2 production. Supplemental GSH significantly inhibited activation of NF-κB, resulting in a decreased production of DV2 in HepG2 cells. Furthermore, high activity of NF-κB and increased production of DV2 was observed in HepG2 cells treated with buthionine sulfoximine (BSO), an inhibitor of GSH synthesis. In conclusion, DV2 infection could reduce host intracellular GSH concentration and benefited from this process. Supplemental GSH could inhibit viral production, indicating GSH might be valuable in the prevention and treatment of DV2 infection.

Keywords
Dengue virus, Redox stage, GSH, NF-κB

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