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Changes in certain hematological and physiological variables
following single gallium arsenide exposure in rats.; PY1997;Defense Research
& Development Establishment, Gwalior, India (印度);_WJD_2019-0902_V001R01_IR92_RvD20190902_
Source (資訊來源):
Info cited on 2019-09-02-WD1 (資訊引用於 中華民國108年9月2日) by 湯偉晉
(WeiJin Tang)
#
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Biol Trace Elem Res. 1997 Sep;58(3):197-208.
Changes in certain hematological and physiological variables
following single gallium arsenide exposure in rats.
Changes
in certain hematological and physiological variables following single gallium
arsenide exposure in rats.
Changes in certain hematological and physiological variables
following single gallium arsenide exposure in rats.
Flora SJ1, Dube SN, Vijayaraghavan R, Pant SC.
Author information
1
Division of Pharmacology and Toxicology, Defense Research
& Development Establishment, Gwalior, India.
Abstract
Gallium
arsenide (GaAs), a group III-VA intermetallic semiconductor, possesses
superior electronic and optical properties and has a wide application in
electronic industry. Exposure
to GaAs in the semiconductor industries could be a possible occupational risk. The
aim of the present study was to determine the dose-dependent effect of single oral exposure to
GaAs (500, 1000, or 2000 mg/kg) on some biochemical variables in heme synthesis pathway and
few selected physiological
variables at d 1, 7, and 15 following administration. The results
indicate that GaAs produced a significant effect on the activity of
delta-aminolevulinic acid dehydratase (ALAD) in blood and heart (particularly
at d 7) following exposure to 2000 mg/kg, whereas
urinary delta-aminolevulinic acid (ALA) excretion was elevated only at d 7.
No marked influence of GaAs on blood hemoglobin, zinc
protoporphyrin, and packed cell volume was noticed. Blood glutathione (GSH) was significantly
reduced at d 7, but remained unchanged at two
other time intervals. On the other hand, heart GSH contents remained uninfluenced on GaAs
exposure. Most of the physiological variables, viz. blood pressure, heart and
respiration rate, and twitch response, remained unchanged, except for some
minor alterations observed at d 7 and 15 following exposure to GaAs at a dose
of 2000 mg/kg. Blood gallium concentration was not detectable in normal animals
and rats exposed to 500 mg/kg GaAs. Blood arsenic concentration was, however,
detectable even at the a lower dose level and increased in a dose-dependent
manner. All these changes
showed a recovery pattern at d 21, indicating that the alterations are
reversible.
PMID: 9403132
[Indexed for MEDLINE]
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