A role for glutathione in muscle contraction PY1970 IR94 IR95
A role for glutathione in muscle contraction PY1970 IR94 IR95
“A role for glutathione in muscle contraction”
Scientific Research Activities by WeiJin Tang (湯偉晉 在進行的 科學性研究活動); By WeiJin Tang (湯偉晉); Email: WeiJin.Tang@gmail.com; Cell phone: 0958-227-243 (Taiwan)
A role for glutathione in muscle contraction PY1970 IR94 IR95
A role for glutathione in muscle contraction PY1970 IR94 IR95
“A role for glutathione in muscle contraction”
The glutathione defense system in the pathogenesis of rheumatoid arthritis (類風濕性關節炎) PY2001 IR95
在 類風濕性關節炎 發病過程中的 穀胱甘肽 防禦系統
資訊來源 2023-0612:
https://pubmed.ncbi.nlm.nih.gov/11180282/
#湯偉晉挑選的醫學論文
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J Appl Toxicol
2001 Jan-Feb;21(1):69-73. doi: 10.1002/jat.736.
The glutathione defense system in the pathogenesis of rheumatoid arthritis
在 類風濕性關節炎 發病過程中的 穀胱甘肽 防禦系統
M Q Hassan 1 , R A Hadi, Z S Al-Rawi, V A Padron, S J Stohs
Affiliation
1 Faculty of Pharmacy & Medical Sciences, Amman University, Amman 19328, Jordan.
PMID: 11180282 DOI: 10.1002/jat.736
Abstract
In order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (類風濕性關節炎) (RA), serum reduced glutathione levels (GSH), glutathione reductase (GSR), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and alkaline phosphatase (ALP) activities, lipid peroxidation (MDA content) and indexes of inflammation were evaluated in 58 rheumatic patients.
重點
Rheumatoid athritis was associated with significant depletion (ca. 50%) in GSH levels compared with normal control subjects. Serum levels of the detoxifying enzymes GSR and GSH-Px decreased by ca. 50% and 45%, respectively, whereas a threefold increase in the activity of GST was observed.
A 1.2-fold increase in ALP was observed in patients with RA. These effects were accompanied by a 3.1-fold increase in serum MDA content. The MDA content was higher in RA patients who were seropositive for rheumatoid factor as well as positive for C-reactive proteins.
重點
The erythrocyte sedimentation rate for all patients with RA was approximately 13.8-fold higher than for the control group, and was higher among RA patients who were positive for C-reactive proteins and exhibited seropositivity for rheumatoid factor.
Patients with RA receiving gold therapy exhibited significantly lower MDA levels whereas all other factors that were measured were not effected.
重點
The results support a hypothesis that defense mechanisms against reactive oxygen species are impaired in RA.
Copyright 2001 John Wiley & Sons, Ltd.
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Mechanisms of photosensitization PY1983 glutathione IR95
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Photochem Photobiol
. 1983 Dec;38(6):745-51. doi: 10.1111/j.1751-1097.1983.tb03610.x.
Mechanisms of photosensitization
A W Girotti
PMID: 6366837 DOI: 10.1111/j.1751-1097.1983.tb03610.x
No abstract available
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S-Glutathionylation: From Molecular Mechanisms to Health Outcomes PY2011 IR95 Glutathione as a biological redox buffer
資訊來源:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110090/
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Glutathione as a biological redox buffer.
重要重點
Glutathione as a biological redox buffer. The ratio of GSH/GSSG reflects the redox capacity of the cell. The ratio is kept in balance through oxidation/reduction reactions involving GSH peroxidase and GSH reductase. Reactive oxygen species-/reactive nitrogen species-induced changes that decrease GSH lead to cell death via apoptosis or necrosis.
GP, GSH peroxidase; GR, GSH reductase; GSH, reduced glutathione; GSSG, oxidized glutathione.
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重要重點
Intracellular GSH levels are governed by the rate of de novo GSH synthesis and export. GSH cannot freely cross the cell membrane and as such there are GSH transporters in some tissues and enzymes that facilitate catalysis and uptake. In general, GSH must be catabolized via a salvage pathway and the constitutive amino acids brought into the cell for subsequent de novo synthesis.
重點
To date, only one enzyme is known to facilitate this process. Gamma-glutamyltransferase (GGT) is a cell surface heterodimeric glycoprotein expressed at high levels in kidney tubules, biliary epithelium, and brain capillaries (112). GGT catalyzes the degradation of extracellular GSH, hydrolyzing the γ-glutamyl bond between glutamate and cysteine and releasing the product cysteinyl-glycine (CG) and glutamate. CG is cleaved by the membrane-bound dipeptidase to cysteine and glycine (Fig. 2). The resulting cysteine can be transported into the cell. This salvage supplements the constitutive amino acids required for de novo synthesis, achieved by sequential catalytic steps involving γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase. The γ-GCS reaction represents the committed step in the biosynthesis and is subject to feedback inhibition by GSH, but cysteine is rate limiting. Reactions of GSH can be subdivided into those involving the γ-glutamyl and those of the sulfhydryl of cysteine. The amino terminal peptide bond is formed through the γ-carboxyl of the glutamate residue. This bond is resistant to degradation by serum proteolytic enzymes and this allows interorgan transport of GSH.
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Measurement of electron density and temperature in an annular magnetically confined cold-cathode plasma of helium by optical emission spectroscopy PY2022 中國,氦氣,氦原子,電子的密度
資訊來源:
德國的博士論文:
Electron Density in a Helium Discharge Plasma
https://www.uni-frankfurt.de/49398667/bachelorarbeit_christian_kuechler.pdf
關鍵字詞:
electron density map, helium
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RESEARCH ARTICLE JANUARY 28 2022
Measurement of electron density and temperature in an annular magnetically confined cold-cathode plasma of helium by optical emission spectroscopy
Hao Sun ; Yushi Zhang ; Lingxiao Li ; Yi Wu; Mingzhe Rong
Crossmark: Check for Updates
Author to whom correspondence should be addressed: wuyic51@mail.xjtu.edu.cn
Physics of Plasmas 29, 013511 (2022)
https://doi.org/10.1063/5.0067380
Magnetically confined cold-cathode plasmas in monatomic gases like helium can be used in a variety of devices and applications. In this paper, the radial distribution of electron temperature and electron density in cold-cathode helium plasmas constrained by an annular magnetic field were studied by optical emission spectroscopy. Helium plasma was generated under different pressures (7.5, 10, and 20 Pa) and values of current (23.5 and 33 mA). The spectral lines of He I 667.8 and He I 501.6 nm were studied and the Stark broadening method was applied to obtain the radial distributions of electron temperature and electron density. The results indicate that higher radial gradients or peak values of both electron density and electron temperature could be achieved with increasing operating pressures and discharge currents. It was found that the electrons were mainly concentrated in the area of the localized cusp magnetic field near the cathode surface and the electron density decreased rapidly as with the decrease in the magnetic field.
Topics
Electron density, Doppler effect, Integral transforms, Stark effect, Chemical elements, Cold cathodes, Optical emission spectroscopy, Gaussian broadening, Gas discharges, Plasmas
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## 2023-0419 湯偉晉日期
重要的科學技巧
使用無線電頻率來鑑定或是辨識化學物品
identify chemicals with radio frequencies - nuclear quadrupole resonance (MRI without magnet)
開始_電腦翻譯的中文
識別具有無線電頻率的化學物質 - 核四極共振(無磁鐵的 MRI)
結束_電腦翻譯的中文
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identify chemicals with radio frequencies - nuclear quadrupole resonance (MRI without magnet)
identify chemicals with radio frequencies - nuclear quadrupole resonance (MRI without magnet)
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