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2019-01-15
Glutathione is required for intestinal function.
[1990];_WJD_2019-0115_V001R01_IR94_
Source (資訊來源):
https://www.ncbi.nlm.nih.gov/pubmed/2308931
Info cited on 2019-01-15-WD2 (資訊引用於 中華民國108年1月15日) by 湯偉晉 (WeiJin Tang)
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Proc Natl Acad Sci U S A. 1990 Mar;87(5):1715-9.
Glutathione is required for intestinal function.
Glutathione is
required for intestinal function.
Glutathione is required for intestinal function.
Mårtensson J1, Jain A, Meister A.
Author information
1
Department of Biochemistry, Cornell University Medical College, New York, NY
10021.
Abstract
Glutathione (GSH) deficiency
produced in mice by giving buthionine sulfoximine leads to severe degeneration
of the epithelial cells of the jejunum and colon. This is prevented by giving GSH monoester (orally or i.p.)
and also by giving GSH
(orally, but not i.p.). The i.p. administration leads to high plasma levels
of GSH but does not
appreciably increase GSH levels in intestinal mucosa or pancreas. These
and previous studies on lens, lung, lymphocytes, liver, heart, and skeletal
muscle indicate that there is
very little, if any, transport of intact GSH from plasma to these tissues.
Cells can use extracellular GSH by a pathway involving its cleavage, uptake of
products and intracellular GSH synthesis. Epithelial cells of the
gastrointestinal tract may use this pathway and can also take up lumenal GSH
(which arises partly from the bile) by a mechanism(s) that may involve
transport of dipeptides or of GSH. It is suggested that biliary GSH normally functions in the protection of
intestinal mucosa. Administration
of GSH may be protective of the gastrointestinal epithelium and may also serve
as a good source of cysteine moieties for intracellular GSH synthesis in the
gastrointestinal tract and in other tissues. Administration of GSH
delivery agents such as GSH
esters is more
effective than administration of GSH in increasing cellular and mitochondrial
levels of GSH.
PMID: 2308931 PMCID: PMC53553
[Indexed for MEDLINE] Free PMC Article
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