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2019-01-15
Glutathione, a first line of defense against cadmium toxicity. [1987]; Meister,
Cornell University;_WJD_2019-0115_V001R01_IR94_
Source (資訊來源):
https://www.ncbi.nlm.nih.gov/pubmed/2887478
Info cited on 2019-01-15-WD2 (資訊引用於 中華民國108年1月15日) by 湯偉晉 (WeiJin Tang)
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FASEB J. 1987 Sep;1(3):220-3.
Glutathione, a first line of defense against cadmium toxicity.
Glutathione, a first
line of defense against cadmium toxicity.
Glutathione, a first line of defense against cadmium toxicity.
Singhal RK, Anderson ME, Meister A.
Abstract
Experimental modulation of cellular glutathione levels has been used to explore
the role of glutathione in cadmium toxicity. Mice treated with buthionine
sulfoximine [an effective irreversible inhibitor of gamma-glutamylcysteine
synthetase (EC 6.3.2.2) that decreases cellular levels of glutathione markedly]
were sensitized to the toxic effects of CdCl2. Mice pretreated with a sublethal
dose of Cd2+ to induce metallothionein synthesis were not sensitized to Cd2+ by
buthionine sulfoximine. Mice sensitized to Cd2+ by buthionine sulfoximine were
protected against a lethal dose of Cd2+ by glutathione mono isopropyl ester
(L-gamma-glutamyl-L-cysteinylglycylisopropyl ester), but not by glutathione. These
results are in accord with studies that showed that glutathione mono esters (in
contrast to glutathione) are efficiently transported into cells and converted
intracellularly to glutathione. The findings indicate that intracellular glutathione functions in
protection against Cd2+ toxicity, and that this tripeptide provides a first
line of defense against Cd2+ before induction of metallothionein synthesis occurs. The experimental approach used
here in which cellular levels of glutathione are decreased or increased seems
applicable to investigation of other types of metal toxicity and of other
glutathione-dependent biological phenomena.
PMID: 2887478
[Indexed for MEDLINE]
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