---
- - --- - - ---
2019-01-15
Cysteine／Glutathione
Deficiency： A Significant and
Treatable Corollary of Disease; In book： The Therapeutic Use
of N-Acetylcysteine (NAC) in Medicine; Stanford University [2019];_WJD_2019-0115_V001R01_IR94_
Source (資訊來源):
https://www.researchgate.net/publication/327799571_CysteineGlutathione_Deficiency_A_Significant_and_Treatable_Corollary_of_Disease
Info cited on 2019-01-15-WD2 (資訊引用於 中華民國108年1月15日) by 湯偉晉 (WeiJin Tang)
#
- - - - - - - -
Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of
Disease
Cysteine/Glutathione
Deficiency: A Significant and Treatable Corollary of Disease
Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of
Disease
Chapter (PDF Available) · January 2019 with 241 Reads
DOI: 10.1007/978-981-10-5311-5_20
In book: The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine, pp.349-386
Cite this publication
Abstract
Glutathione (GSH) deficiency
may play a pivotal role in a variety of apparently unrelated clinical
conditions and diseases. Orally administered N-acetylcysteine (NAC),
which replenishes the cysteine required for GSH synthesis, has been tested in a
large number of randomized placebo-controlled trials involving these diseases
and conditions. This
chapter focused on developing a base of evidence suggesting that NAC
administration improves disease by increasing cysteine and/or GSH in a variety
of diseases, thereby implying a significant role for GSH deficiency in the
clinical basis of many diseases. To develop this base of evidence, we
systematically selected studies which considered the hypothesis that the
therapeutic efficacy for NAC is an indication that cysteine and/or GSH deficiency is a
pathophysiological part of the diseases studied. In this manner we focus this chapter on
explaining the biological mechanisms of NAC therapy in a wide variety of
disorders and demonstrate its ubiquitous role in improving disease that involves disrupted GSH and/or
cysteine metabolism.
- - - - -- -- - -
--- --- - - --- ---
沒有留言:
張貼留言