Pharmacokinetics of intravenous ATP in cancer patients; PY2000_IR94, Glutathione

Pharmacokinetics of intravenous ATP in cancer patients; PY2000_IR94, Glutathione

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2025-10-04
Pharmacokinetics of intravenous ATP in cancer patients; PY2000_IR94, Glutathione

Source or References (資訊來源或是參考的資訊):
https://pubmed.ncbi.nlm.nih.gov/10853877/
Info cited on 2025-10-04-WD6 (資訊引用於 中華民國114年西元2025年10月4日) by 湯偉晉 (WeiJin Tang)
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Clinical Trial Eur J Clin Pharmacol
. 2000 Apr;56(1):49-55. doi: 10.1007/s002280050719.         
Pharmacokinetics of intravenous ATP in cancer patients

Pharmacokinetics of intravenous ATP in cancer patients

Pharmacokinetics of intravenous ATP in cancer patients
H J Agteresch 1, P C Dagnelie, T Rietveld, J W van den Berg, A H Danser, J H Wilson
Affiliations collapse
Affiliation
1Department of Internal Medicine, Erasmus University Medical Centre Rotterdam, The Netherlands.
PMID: 10853877 DOI: 10.1007/s002280050719
Abstract
Objective: To characterise the pharmacokinetics of adenosine 5'-triphosphate (ATP) in patients with lung cancer after i.v. administration of different ATP dosages.

Methods: Twenty-eight patients received a total of 176 i.v. ATP courses of 30 h. Fifty-two infusions were given as low-dose infusions of 25-40 microg kg(-1) min(-1), 47 as middle-dose infusions of 45-60 microg kg(-1) min(-1) and 77 as high-dose infusions of 65-75 microg kg(-1) min(-1) ATP. Kinetic data of ATP concentrations in erythrocytes were available from 124 ATP courses. Results are expressed as mean +/- SEM.

Results: Most ATP courses in cancer patients were without side effects (64%), and side effects occurring in the remaining courses were mild and transient, resolving within minutes after decreasing the infusion rate. Baseline ATP concentration in erythrocytes was 1,554 +/- 51 micromol l(-1). ATP plateau levels at 24 h were significantly increased by 53 +/- 3, 56 +/- 3 and 69 +/- 2% after low-dose, middle-dose and high-dose ATP infusions, respectively. At the same time, significant increases in plasma uric acid concentrations were observed: 0.06 +/- 0.01, 0.11 +/- 0.01 and 0.16 +/- 0.01 mmol l(-1), respectively. The mean half-time for disappearance of ATP from erythrocytes, measured in five patients, was 5.9 +/- 0.5 h.

Conclusions: During constant i.v. infusion of ATP in lung cancer patients, ATP is taken up by erythrocytes and reaches dose-dependent plateau levels 50-70% above basal concentrations at approximately 24 h.

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