Blood glutathione decreases in chronic diseases; PY2000; University of Louisville School of Medicine, USA (美國);_WJD_2020-0504_V001R01_IR94_

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2020-05-04
Blood glutathione decreases in chronic diseases.
Source (資訊來源):
https://www.ncbi.nlm.nih.gov/pubmed/10811055
Info cited on 2020-05-04-WD1 (資訊引用於 中華民國109年5月4日) by 湯偉晉 (WeiJin Tang)
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J Lab Clin Med. 2000 May;135(5):402-5.

Blood glutathione decreases in chronic diseases.

Lang CA1, Mills BJ, Mastropaolo W, Liu MC.
Author information
1
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, KY 40292, USA.

Abstract
Previously a high blood glutathione level was correlated with long life span in the mouse and rat and in healthy elderly human beings. This raised the question of whether low glutathione levels occur in unhealthy subjects. To this end, 74 consecutive patients newly admitted to the hospital, with ages ranging from 21 to 89 years and diagnosed with chronic diseases, were studied along with 32 healthy control subjects. Blood samples were analyzed for reduced (GSH) and oxidized (GSSG) glutathione with a high-performance liquid chromatography-dual electrochemical method. The data were integrated with the clinical diagnoses and statistically analyzed. Marked total glutathione decreases from the control levels occurred in over 36% of the patients with chronic diseases including cancer and genitourinary, gastrointestinal, cardiovascular, and musculoskeletal diseases (P < .001). The deficit was due to low GSH concentrations and not to GSSG, which was the same as that in the control subjects. The conclusion is that a decrease in GSH is a risk factor for chronic diseases that may be used to monitor the severity and progress of the diseases. Future work is necessary to elucidate the mechanism of action.

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以前，高穀胱甘肽水平與小鼠和大鼠以及健康老年人的壽命長有關。這就提出了一個問題，即在不健康的受試者中是否發生了低穀胱甘肽水平。為此，與32名健康對照受試者一起研究了74名新入院的連續患者，年齡在21至89歲之間，並被診斷出患有慢性疾病。使用高效液相色譜-雙電化學方法分析血樣中的還原型（GSH）和氧化型（GSSG）穀胱甘肽。數據與臨床診斷整合併進行統計分析。超過36％的慢性疾病患者（包括癌症和泌尿生殖系統，胃腸道，心血管和肌肉骨骼疾病）的總穀胱甘肽水平明顯低於對照組（P <.001）。缺乏症是由於GSH濃度低而不是GSSG引起的，與對照組相同。結論是，穀胱甘肽降低是慢性疾病的危險因素，可用於監測疾病的嚴重程度和進展。為了闡明作用機理，未來的工作是必要的。
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PMID: 10811055 DOI: 10.1067/mlc.2000.105977

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