ABCG2: structure, function and role in drug response. [2008](IR91)

ABCG2: structure, function and role in drug response. [2008](IR91)

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on December 16, 2010 10:48 PM)
- - - Begin title or keyword:
ABCG2: structure, function and role in drug response.

http://www.ncbi.nlm.nih.gov/pubmed/18370855
- - - End title or keyword:

Expert Opin Drug Metab Toxicol. 2008 Jan;4(1):1-15.
ABCG2: structure, function and role in drug response.
Polgar O, Robey RW, Bates SE.
National Cancer Institute, Medical Oncology Branch, Center for Cancer Research, NIH, 9000 Rockville Pike, Building 10, Room 13N240, Bethesda, MD 20892, USA.

Abstract
ABCG2 was discovered in multi-drug-resistant cancer cells, with the identification of chemotherapeutic agents, such as mitoxantrone, flavopiridol, methotrexate and irinotecan as substrates. Later, drugs from other therapeutic groups were also described as substrates, including antibiotics, antivirals, HMG-CoA reductase inhibitors and flavonoids. An expanding list of compounds inhibiting ABCG2 has also been generated. The wide variety of drugs transported by ABCG2 and its normal tissue distribution with highest levels in the placenta (胎盤), intestine and liver, suggest a role in protection against xenobiotics. ABCG2 also has an important role in the pharmacokinetics (藥物動力學) of its substrates. Single nucleotide polymorphisms of the gene were shown to alter either plasma concentrations of substrate drugs or levels of resistance against chemotherapeutic agents in cell lines. ABCG2 was also described as the determinant of the side population of stem cells. All these aspects of the transporter warrant further research aimed at understanding ABCG2's structure, function and regulation of expression.

PMID: 18370855 [PubMed - indexed for MEDLINE]
// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on December 16, 2010 10:51 PM)
- - - Begin title or keyword:
Common added by WeiJin Tang (湯偉晉)
- - - End title or keyword:

Known GSH transporter
Glutathione Transport Is a Unique Function of the ATP-binding Cassette Protein ABCG2

ABCG2 is a GSH transporter

Source; URL of the source or Name of the professional paper:
Glutathione Transport Is a Unique Function of the ATP-binding Cassette Protein ABCG2 [2010[(IR91)
http://www.jbc.org/content/285/22/16582
// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on December 16, 2010 10:56 PM)
- - - Begin title or keyword:
Auxiliary info for understanding this paper
- - - End title or keyword:

Pharmacokinetics
藥物動力學
pharmacokinetics (藥物動力學)

The branch of pharmacology concerned with the movement of drugs within the body.

The study of the action of drugs in the body: method and rate of excretion; duration of effect; etc.
Source:
wordnetweb.princeton.edu/perl/webwn

large intestine
大腸
small intestine
小腸
intestine
腸子

// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //